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1990
Stanley Korsmeyer, MD, determines that a cancer gene, bcl-2, does not make cells proliferate as expected but instead blocks "programmed cell death," a novel mechanism for carcinogenesis. The National Institutes of Health (NIH) establishs a Human Genome Center under the direction of David Schlessinger, PhD.

A group of scientists headed by Robert Waterston, MD, begins sequencing the genome of a roundworm, C. elegans, with pilot funding from the NIH.

The world's first laparascopic kidney removal for a renal tumor is performed at Barnes Hospital by Ralph Clayman, MD, and Lou Kavoussi, MD, assisted by Nathaniel Soper, MD.
1991
MIR opens the St. Louis area's first 3-D treatment planning center for cancer. This kind of treatment allows radiation oncologists and physicists to tailor radiation dosage to each tumor, with less irradiation of surrounding normal tissues.

The world's first endoscopic nephro-ureterectomy for upper-tract transitional cell carcinoma is performed at Barnes Hospital by Ralph Clayman, MD, and Lou Kavoussi, MD, assisted by Sherb Figenshau, MD, and Dave Albala, MD.
1993
The group of scientists headed by Robert Waterston, Ph.D. — now called the Genome Sequencing Center — receives a $42 million grant from the NIH to continue the C. elegans sequencing project.

Washington University School of Medicine is chosen as one of nine sites nationally to participate in the largest randomized prospective cancer screening study ever undertaken for prostate, lung, colorectal and ovarian cancers.This PLCO trial, with Gerald Andriole, MD, as principal investigator, will screen 150,000 patients nationally and 12,000 in St. Louis by 1999.

A research team led by Helen Donis-Keller, PhD, identifies the genetic mutation that causes several forms of multiple endocrine neoplasia (MEN).

Cancer Information and Resource Center for Life and Education (CIRCLE) opens with the support of the Jewish Hospital Auxiliary.
1994
The Division of Bone Marrow Transplantation and Stem Cell Biology is created under the leadership of John DiPersio, MD, PhD, and grows into one of the four largest programs of its type in the world, with more than 238 transplants in 1999.

The laboratory of Lee Ratner, MD, is the first to develop an infectious molecular clone of a human T-cell leukemia virus to identify the mechanism of leukemia.

Samuel Wells, MD, and other researchers find that blood tests designed to determine which people in a high-risk family will develop MEN are virtually 100 percent accurate.
1995
William Catalona, MD, begins a study that shows a free PSA test can improve the accuracy of PSA screening. The results are published in Journal of the American Medical Association in May 1998.

John DiPersio, MD, Randy Brown, MD, and Douglas Adkins, MD, pioneer new advances in bone marrow transplantation, including using peripheral blood and cord blood as sources of stem cells in allogeneic recipients.

Washington University Medical Center receives an NCI P20 Cancer Center Planning Grant.

 

 

 

 



 

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1996
The NIH awards the Genome Sequencing Center a three-year, $24 million grant to test the feasibility of sequencing the human genome.

Oncology programs at Barnes Hospital and the Jewish Hospital of St. Louis merge.

The Hereditary Cancer Program begins at Barnes-Jewish Hospital to help people with a family history of a certain cancer assess the risk for developing it.
1896 - 1956 
1957 - 1988 
 1997 - 2001
2002 - 2005