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Komen Affiliate Honors Siteman Breast Cancer Researcher

Helen Chesnut, executive director of the St. Louis affiliate of Susan G. Komen for the Cure, presents the affiliate's 2013 Health Professional of the Year Award to Ron Bose, MD, PhD.

April 25, 2013 – Siteman Cancer Center medical oncologist Ron Bose, MD, PhD, has received the 2013 Health Professional of the Year Award
from the St. Louis affiliate of Susan G. Komen for the Cure.

Bose, assistant professor of medicine at Washington University School of Medicine, received the honor during Komen St. Louis’ fourth annual Power of a Promise luncheon on April 21. He was recognized for his breast
cancer research, which focuses on the HER2 (human epidermal growth factor receptor 2) gene.

HER2 is a gene that makes proteins that encourage cancer cell growth. Recently, through DNA sequencing studies, Bose and colleagues determined that current tests used to measure HER2 in breast cancer don’t detect all types of HER2 mutations, so some women may not receive the necessary drugs that target this cancer promoter.

Bose presented data from this study Dec. 7 at the San Antonio Breast Cancer Symposium.

The study’s findings led to the launch of a clinical trial to test whether patients with HER2 mutations might benefit from anti-HER2 drugs. Their HER2 genes will be sequenced to look for mutations. If mutations are present, they will be treated with the drug neratinib, which targets HER2, in addition to the standard treatment they would otherwise receive.

Bose’s work has been previously recognized by Susan G. Komen for the Cure. He received a Komen Postdoctoral Fellowship Grant in 2005 and a Komen Career Catalyst Research Grant in 2009.