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ChemoHormonal Therapy versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer.
The purpose of this study is to determine whether giving docetaxel chemotherapy, at the time you are starting hormonal therapy and when the hormonal therapy is no longer working, is more effective than giving it only at the time the hormonal therapy is no longer working. Hormonal therapy refers to drugs or surgical procedures such as an orchiectomy (removal of one or both testicles) used to lower your testosterone. This puts prostate cancer into remission in most patients as the testosterone is like a fuel for the cancer. It is the standard to give this as the only treatment for your cancer. Normally chemotherapy is reserved for when a patient’s cancer starts to grow again despite having a low testosterone level. In this study you will either get docetaxel when you start your hormonal therapy or when/if your cancer grows with a low testosterone level. If you have chemotherapy when you start hormones for the first time, you may get chemotherapy when/if your cancer grows back with a low testosterone level.
About 568 people will take part in this study with approximately 15 being from Washington University.
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