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A Phase III Trial of Pelvic Radiation Therapy versus Vaginal Cuff Brachytherapy Followed by Paclitaxel Carboplatin Chemotherapy in Patients with High Risk, Early Stage Endometrial Carcinoma
Endometrial cancer is commonly treated with surgery. You have already had surgery including hysterectomy (Removal of the uterus), removal of the ovaries, and possibly the removal of pelvic and para-aortic lymph nodes. Following your surgery, your doctor has identified you to have risk factors related to the cancer which place you at a greater risk for the cancer coming back (recurrence).
In this study you will receive either radiation therapy to the pelvis (standard of care) or vaginal radiation therapy combined with 3 cycles of the chemotherapy drugs paclitaxel and carboplatin. You will not get both. Vaginal cuff brachytherapy is a newer method for delivering radiation therapy. The combination of vaginal cuff brachytherapy followed by chemotherapy is considered the investigational arm of this study.
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