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Number: GOG 0249 Principal Investigator: Mutch, David
Title: A Phase III Trial of Pelvic Radiation Therapy versus Vaginal Cuff Brachytherapy Followed by Paclitaxel Carboplatin Chemotherapy in Patients with High Risk, Early Stage Endometrial Carcinoma
Phase: III Disease Site: Corpus Uterus
Participating Site(s):
 
 
Contact: 800-600-3606 or info@ccadmin.wustl.edu
Description:
Endometrial cancer is commonly treated with surgery. You have already had surgery including hysterectomy (Removal of the uterus), removal of the ovaries, and possibly the removal of pelvic and para-aortic lymph nodes. Following your surgery, your doctor has identified you to have risk factors related to the cancer which place you at a greater risk for the cancer coming back (recurrence).

In this study you will receive either radiation therapy to the pelvis (standard of care) or vaginal radiation therapy combined with 3 cycles of the chemotherapy drugs paclitaxel and carboplatin. You will not get both. Vaginal cuff brachytherapy is a newer method for delivering radiation therapy. The combination of vaginal cuff brachytherapy followed by chemotherapy is considered the investigational arm of this study.
 
More Information:
Internal Protocol Documents (requires Siteman administrative database password)