Number: 201011804 Principal Investigator: Fontana, Luigi
Title: Does Protein Restriction Inhibit Prostate Cancer Growth?
Phase: N/A Disease Site: Prostate
Participating Site(s):
Main Campus
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The purpose of this study is to test the hypothesis that a low protein diet will inhibit prostate cancer growth. We propose to study two groups of prostate cancer patients: 38 men scheduled to undergo radical prostatectomy, and 44 men with persistently elevated prostate-specific antigen (PSA) after radical prostatectomy. Both groups will be randomized either to standard treatment or a low protein diet (~0.8 g protein per Kg fat free body mass). Outcome measurements include plasma levels of PSA (prostate specific antigen, a measure of prostate cell growth), IGF (insulin-like growth factor, a hormone that stimulates prostate and other types of cells to grow), insulin, interleukin 6 and HsCRP (indicators of the amount of inflammation), testosterone and sex hormone-binding globulin (a protein that binds to testosterone in the blood). Histopathology (examination under a microscope) and gene expression evaluation (a way of telling if the genes that control cancer cell growth are more or less active) of the prostate samples will be performed in the prostate cancer patients undergoing radical prostatectomy. We will also develop an in vitro (means not in the body; laboratory procedure using test tubes or petri dishes). model of protein restriction to study the genomic (changes in gene activity) and cellular effects of serum (blood sample) obtained from prostate cancer patients (before and after protein restriction) on normal and prostate cancer cell lines (cells purchased for laboratory experiments).

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