| Number: 201207059 |
Principal Investigator: Haughey, Bruce |
| Title: Adjuvant De-escalation, Extracapsular Spread, P16+, Transoral (ADEPT) Trial for Oropharhynx Malignancy |
| Description: This research study is looking at cancer of
the oropharynx (tonsil and/or base of the tongue) which has been shown to be related to the human papillomavirus (HPV) and which has lymph nodes showing extracapsular spread, meaning that the cancer in the lymph nodes is exposed to the soft tissue around ...MORE |
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| Number: 201205124 |
Principal Investigator: Uppaluri, Ravindra |
| Title: A Phase II Window of Opportunity Trial with GSK1120212 in Surgically Resectable Oral Cavity Squamous Cell Cancer |
| Description: The purpose of this research study is test the investigational drug GSK1120212 over the course of the two weeks prior to your surgery to see whether the treatment results in any changes to your tumor....MORE |
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| Number: 201202113 |
Principal Investigator: Adkins, Douglas |
| Title: Phase II Trial of nab-Paclitaxel, Cisplatin, and 5-FU (ACF) as Induction Therapy followed by Definitive Concurrent Chemoradiation for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (HNSCC) |
| Description: This phase II trial studies the safety and effectiveness of an induction chemotherapy (ACF) consisting of paclitaxel albumin-stabilized nanoparticle formulation (nab-paclitaxel), cisplatin and fluorouracil followed by chemoradiation therapy in treating patients with stage III-IV squamous cell cancer...MORE |
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| Number: 201106342 |
Principal Investigator: Thorstad, Wade |
| Title: Phase II Trial Evaluating Elimination of Radiation Therapy to Pathological N0 Neck(s) with Intensity Modulated Postoperative Radiation Therapy |
| Description: The purpose of this study is to determine if reducing or eliminating radiation treatment to one or both sides of the neck where there is no evidence of cancer can help spare you of the side effects of radiation treatment for head and neck cancer. In this study, we plan to reduce the amount of radiat...MORE |
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| Number: P2C 8692 |
Principal Investigator: Adkins, Douglas |
| Title: A T1 Translational Multicenter Randomized Phase II Study of Temsirolimus versus Cetuximab Plus Temsirolimus in Patients with Recurrent / Metastatic Head and Neck Cancer, Who Failed Prior EGFR Based Therapy |
| Description: The purpose of this research study is to learn if Temsirolimus (TORISEL®) alone or in combination with Cetuximab (ERBITUX®) can potentially have an effect on head and neck cancers in people who were previously treated with Cetuximab (or another agent in the same class [EGFR inhibitors]) but no longe...MORE |
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| Number: 201102048 |
Principal Investigator: Adkins, Douglas |
| Title: Randomized Double- Blind Phase II Trial of Everolimus Versus Placebo as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN) |
| Description: The purpose of this clinical research study is to see if Everolimus helps keep head and neck cancer from coming back after patients complete regular treatment....MORE |
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| Number: RTOG 1016 |
Principal Investigator: Thorstad, Wade |
| Title: Phase III Trial of Radiotherapy plus Cetuximab Versus Chemoradiotherapy in HPV-associated Oropharynx Cancer |
| Description: The purpose of this study is to compare the effects, good and/or bad, of two standard treatments for head
and neck cancer: radiation therapy and cisplatin or radiation therapy and cetuximab. The two treatments
may be comparable in treating your cancer, but radiation and cetuximab may result in les...MORE |
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| Number: RTOG 0920 |
Principal Investigator: Thorstad, Wade |
| Title: A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab For Locally Advanced Resected Head and Neck Cancer
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| Description: The purpose of this study is to compare the effects, good and/or bad, of radiation therapy alone with radiation therapy and cetuximab on you and your cancer to find out which is better. In this study, you will get either radiation therapy alone OR radiation therapy and cetuximab.
If you participate...MORE |
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| Number: CTSU E1305 |
Principal Investigator: Adkins, Douglas |
| Title: A Phase III Randomized Trial of Chemotherapy with or without Bevacizumab In Patients with Recurrent or Metastatic Head and Neck Cancer |
| Description: You may be asked to participate in this study if you have head and neck cancer for which there is no curative therapy.
The purpose of this study is to compare the effects (good and bad) of the addition of a drug called bevacizumab to the standard chemotherapy to see which works better. We will d...MORE |
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| Number: 201102133 |
Principal Investigator: Thorstad, Wade |
| Title: Functional and Quality of Life Assessment in Head and Neck Cancer Patients Status Post Radiation Therapy |
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| Number: 201110089 |
Principal Investigator: Haughey, Bruce |
| Title: Observational Study of Swallowing Function after Treatment of Advanced Laryngeal Cancer |
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| Number: 201108088 |
Principal Investigator: Thorstad, Wade |
| Title: Modeling of Dosimetric and Biological Markers of Outcomes in Head and Neck Cancer |
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| Number: 201102323 |
Principal Investigator: Gay, Hiram |
| Title: Analysis of Histological, Genomic, Molecular, and Clinical Factors in Head and Neck Cancer: The Tissue Acquisition Protocol (TAP) |
| Description: The purpose of this research study is to discover genetic changes associated with cancer by documenting the DNA changes that occur in head and neck cancer cells. This may lead to better ways of preventing, detecting, and treating cancer and perhaps other diseases as well....MORE |
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| Number: 201302043 |
Principal Investigator: Sand, Jordan |
| Title: Incidentally identified P16 positive oropharyngeal tumors |
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| Number: 201301030 |
Principal Investigator: Nussenbaum, Brian |
| Title: BMP-2 as a prognostic biomarker and possible therapeutic target for head and neck cancer |
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| Number: 201111208 |
Principal Investigator: El-Mofty, Samir |
| Title: HPV-related squamous cell carcinoma of the head and neck skin in kidney transplant patients |
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| Number: 201110274 |
Principal Investigator: Lewis Jr., James |
| Title: Genetic Markers of Prognosis in HPV-Related Oropharyngeal Squamous Cell Carcinoma |
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| Number: 201107372 |
Principal Investigator: Chernock, Rebecca |
| Title: Evaluation of proliferative verrucous leukoplakia (PVL) lesions for viral genomic sequences |
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| Number: 201104011 |
Principal Investigator: Lewis Jr., James |
| Title: HPV and Tumor Protein Expression in Histologic Variants of Squamous Cell Carcinoma of the Head and Neck |
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