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CLINICAL TRIAL SEARCH RESULTS

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 Number: 201012832 Principal Investigator: Bradley, Jeffrey
Title: A Phase I/II Trial of Stereotactic Body Radiation therapy (SBRT) Dose Escalation in the Treatment of Patients with Inoperable Stage I/II Non-Small Cell Lung Cancer Arising within the Zone of the Proximal Bronchial Tree
Description: The usual treatment for early stage lung cancer is to remove the cancer with surgery. However, when patients have other serious health problems like emphysema, diabetes, or heart disease, they may not be able to have the standard surgery. Patients who cannot have surgery usually receive radiat...MORE
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 Number: 201311115 Principal Investigator: Waqar, Saiama
Title: A Multi-Center, Randomized, Double-Blind Phase II Study Comparing ABT-888, a PARP Inhibitor, versus Placebo with Temozolomide in Patients with Relapsed Sensitive or Refractory Small Cell Lung Cancer
Description: The purpose of this study is to find out what effects, good and/or bad, temozolomide paired with ABT-888 or placebo has on patients with small cell lung cancer that has returned or progressed....MORE
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 Number: 201209007 Principal Investigator: Puri, Varun
Title: Pulmonary Rehabilitation before Lung Cancer Resection
Description: The purpose of this research study is to see how effective a short program (10 sessions) of pre-surgery pulmonary rehabilitation (PR) is on your recovery from the lung cancer surgery....MORE
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 Number: RTOG 1306 Principal Investigator: Govindan, Ramaswamy
Title: A Randomized Phase II Study of Individualized Combined Modality Therapy for Stage III Non-Small Cell Lung Cancer (NSCLC)
Description: The purpose of this study is to determine whether adding treatment with either erlotinib or crizotinib prior to standard treatment with chemotehrapy and radiation helps to better control lung cancer in patients who have tumors with specific changes that make them sensitive to these drug....MORE
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 Number: RTOG 1106 Principal Investigator: Bradley, Jeffrey
Title: Randomized Phase II Trial of Individualized Adaptive Radiotherapy Using During-Treatment FDG-PET/CT and Modern Technology in Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Description: The purpose of this research study is to find out if more intense (higher dose) radiation treatment based on the FDG-PET/CT imaging improves treatment of your cancer with the same possible damage to healthy lung tissue compared to treatment with standard radiation therapy. The higher dose radiation ...MORE
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 Number: RTOG 0937 Principal Investigator: Robinson, Clifford
Title: Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative extra-cranial Irradiation for Extensive Disease Small Cell Lung Cancer (ED-SCLC)
Description: The purpose of this study is to compare the effects, good andlor bad, of radiation given to the brain after chemotherapy to the effects of radiation to the brain, chest and up to 3 other sites (Ie., liver, adrenal gland, bone, etc..) that did not completely respond to treatment after chemotllerapy ...MORE
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 Number: RTOG 0839 Principal Investigator: Robinson, Clifford
Title: Randomized Phase II Study of Pre-operative Chemoradiotherapy +/- Panitumumab Followed by Consolidation Chemotherapy in Potentially Operable Locally Advanced (Stage IIIA, N2+) Non-Small Cell Lung Cancer
Description: This study will compare the effects, good and/or bad, of adding panitumumab to chemotherapy and radiation therapy. In this study, you will get chemotherapy and radiation OR radiation, chemotherapy, and panitumumab. Panitumumab is a drug that may delay or prevent tumor growth by blocking certain cel...MORE
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 Number: CALGB CIRB 30610 Principal Investigator: Baggstrom, Maria
Title: Phase III Comparison of Thoracic radiotherapy Regimens in Patients with Limited Small Cell Lung cancer also Receiving Cisplatin and Etoposide
Description: The purpose of this study is to compare the effects, good and/or bad, of three different ways to give radiation therapy. Two of the ways are experimental, while one of them is standard. The two experimental ways of giving the radiation therapy are (1) once a day with a high dose of radiation for 7 w...MORE
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 Number: 201405034 Principal Investigator: Govindan, Ramaswamy
Title: A randomized, double blind, placebo-controlled, multicenter phase II study to evaluate efficacy and safety of roniciclib in subjects with extensive-stage disease small cell lung cancer (SCLC) who are receiving cisplatin + etoposide or carboplatin + etoposide as first-line therapy
Description: The purpose of this study is to find out if RONICICLIB is effective and safe when given in combination with cisplatin plus etoposide or carboplatin plus etoposide chemotherapy as the first therapy, in extensive disease small cell lung cancer....MORE
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 Number: 201404129 Principal Investigator: Morgensztern, Daniel
Title: TIGER-2: A Phase 2, Open-Label, Multicenter, Safety and Efficacy Study of Oral CO-1686 as 2nd Line EGFR-Directed TKI in Patients with Mutant EGFR Non-Small Cell Lung Cancer (NSCLC) with the T790M Resistance Mutation
Description: The purpose of this research study is to evaluate the safety and anti-tumor effect of the drug CO-1686 in patients whose tumors did not respond or stopped responding to treatment erlotinib, afatinib, or similar drugs....MORE
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 Number: 201402047 Principal Investigator: Morgensztern, Daniel
Title: A phase III, randomized, open-label cross-over, multi-center, safety and efficacy study to evaluate nab-paclitaxel (Abraxane) as maintenance treatment after nab-paclitaxel plus carboplatin in subjects with squamous cell non-small cell lung cancer (NSCLC)
Description: The purpose of this research study is to find out if a drug called nab-paclitaxel (Abraxane®)can help to control non-small cell lung cancer when given after patients have received standard chemotherapy....MORE
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 Number: 201402026 Principal Investigator: Waqar, Saiama
Title: A Randomized, Double-Blind Phase 2 Study of Ruxolitinib or Placebo in Combination with Pemetrexed/Cisplatin and Pemetrexed Maintenance for Initial Treatment of Subjects with Nonsquamous Non-Small cell Lung Cancer That is Stage IIIB with Pleural/Pericardial Effusion, Stage IV or Recurrent
Description: There are two parts to this study; the main purpose of Part 1 of this study is to determine a dose of ruxolitinib that is safe, effective and tolerable in combination with pemetrexed/cisplatin. The main purpose of Part 2 of this study is to find out if taking ruxolitinib when given in combination ...MORE
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 Number: 201401028 Principal Investigator: Govindan, Ramaswamy
Title: A phase I open-label, dose escalation study to investigate the safety, pharmacokinetics, pharmacodynamics and clinical activity of GSK2879552 given orally in subjects with relapsed/refractory small cell lung carcinoma
Description: The purpose of this study is to test the safety of GSK2879552 at different doses. We want to find out what effects, good or bad, it has on people with small cell lung cancer....MORE
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 Number: 201311118 Principal Investigator: Morgensztern, Daniel
Title: Multi-arm, Non-randomized, Open-Label Phase IB Study to Evaluate GSK3052230 in Combination with Paclitaxel and Carboplatin, or Docetaxel or as Single Agent in Subjects with Solid Malignancies and Deregulated FGF Pathway Signaling
Description: The purpose of this study is to find out how well GSK3052230 “GSK230” works against your tumor when given together with chemotherapy or alone....MORE
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 Number: 201310071 Principal Investigator: Waqar, Saiama
Title: A Phase II, Multicenter, Single-Arm Study of MPDL3280A in Patients with PD-L1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Description: The purpose of this study is to evaluate how well MPDL3280A, an investigational drug, is able to treat patients with non-small cell lung cancer that expresses a protein called PD-L1....MORE
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 Number: 201304059 Principal Investigator: Waqar, Saiama
Title: A Phase 2 Study of Neratinib and Neratinib Plus Temsirolimus in Patients with Non-Small Cell Lung Cancer Carrying Known HER2 Activating Mutations
Description: The purpose of this study is to find out whether or not neratinib alone or in combination with temsirolimus can help control lung cancer with a mutation called HER2....MORE
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 Number: 201212027 Principal Investigator: Waqar, Saiama
Title: An Open-label, Randomized Phase IIb/III Active Control Study of Second-line HyperAcute®-Lung (tergenpumatucel-L) Immunotherapy versus Docetaxel in Progressive or Relapsed Non-Small Cell Lung Cancer
Description: The purpose of this study is to assess overall survival of anti-tumor immunization using HyperAcute®-Lung immunotherapy versus Docetaxel in patients with progressed or relapsed non-small cell lung cancer (NSCLC) that have been previously treated....MORE
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 Number: 201211041 Principal Investigator: Baggstrom, Maria
Title: A Study of HSP90 Inhibitor AT13387 Alone and in Combination with Crizotinib in the Treatment of Non-small Cell Lung Cancer (NSCLC)
Description: The purpose of this research study is to look at the safety and tolerability of a drug called AT13387 when given alone or in combination with crizotinib....MORE
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 Number: 201207127 Principal Investigator: Waqar, Saiama
Title: A Phase IIb/III randomized, double-blind, placebo-controlled study comparing first-line therapy with or without TG4010 immunotherapy product in patients with stage IV Non Small Cell Lung Cancer
Description: The purpose of this study is to learn if the combination of TG4010 (an agent designed to stimulate your own immune system) and standard treatment is more effective than standard treatment alone (for this, the standard treatment will be given in combination with placebo, which is an inactive product ...MORE
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 Number: 201207036 Principal Investigator: Govindan, Ramaswamy
Title: A Phase II study of the selective BRAF kinase inhibitor GSK2118436 in subjects with advanced non-small cell lung cancer and BRAF mutations
Description: The purpose of this research study is to test the safety of the drug GSK2118436 (dabrafenib) and how well it works and what effects, good or bad, it has on people with non-small cell lung cancer whose tumors have genetic change called a BRAF mutation....MORE
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 Number: 201107140 Principal Investigator: Parikh, Parag
Title: Evaluating an Anchored Transponder in Lung Cancer Patients Receiving Radiation Therapy
Description: The purpose of this research study is to evaluate a new lung marker (called the anchored transponder) that will be implanted in your lung near the tumor and it will help your doctor give your radiation treatments. The anchored transponders will possibly provide accurate, objective, real time, contin...MORE
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 Number: 201106336 Principal Investigator: Puri, Varun
Title: Prevention of Postoperative Pneumonia (POPP study) A study to evaluate the use of a prophylactic clinical strategy to prevent postoperative pneumonia in patients undergoing thoracic surgery
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 Number: 201202073 Principal Investigator: Robinson, Clifford
Title: Phase I/II trial of lithium as a neuroprotective agent for patients with small cell lung cancer (SCLC) treated with prophylactic cranial irradiation (PCI)
Description: The purpose of this research study is to see how treatment with lithium carbonate affects your memory when taken before and during PCI, as PCI can lead to the development of short term memory problems. Short term memory is the memory you use to remember lists, like grocery lists. Doctors think peopl...MORE
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 Number: 201301108 Principal Investigator: Mardis, Elaine
Title: The Genomics of Acquired Resistance in Non-Small Cell Lung Cancer (NSCLC)
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 Number: 201110275 Principal Investigator: Krupnick, A. Sasha
Title: Immunoregulation of Lung Cancer by Natural Killer Cells
Description: This study is not a treatment trial. The purpose of this research study is to investigate the differences in “natural killer” (NK) blood cells, a type of white blood cell that fights infection in the body, among different types of patients that have lung surgery. This study consists of a one-time ...MORE
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 Number: 201105020 Principal Investigator: Anadkat, Milan
Title: Retrospective and Prospective Data Collection and Analysis of Cutaneous Chemotherapy REACTions at Washington University
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 Number: 201012756 Principal Investigator: Govindan, Ramaswamy
Title: Tissue Source Site (TSS) Network for the Cancer Genome Atlas Project (TCGA)
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 Number: 201301002 Principal Investigator: Chen, Alexander
Title: Radial Endobronchial Ultrasound for the Diagnosis of Peripheral Pulmonary Nodules
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 Number: 201208142 Principal Investigator: Puri, Varun
Title: Predictive Models in Lung Cancer - A Retrospective Institutional Study
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 Number: 201206137 Principal Investigator: Puri, Varun
Title: A study to establish incidence, risk factors, and consequences of postoperative pneumonia after major thoracic surgery
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