| Number: 201011804 |
Principal Investigator: Fontana, Luigi |
| Title: Does Protein Restriction Inhibit Prostate Cancer Growth? |
| Description: The purpose of this study is to test the hypothesis that a low protein diet will inhibit prostate cancer growth. We propose to study two groups of prostate cancer patients: 38 men scheduled to undergo radical prostatectomy, and 44 men with persistently elevated prostate-specific antigen (PSA) after ...MORE |
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| Number: 201102230 |
Principal Investigator: Gay, Hiram |
| Title: A Multi-institutional Phase II Study of Hypofractionated Stereotactic Body Radiation Therapy (SBRT) Using Continuous Real-time Evaluation of Prostate Motion |
| Description: Patients with this condition usually receive radiation therapy in daily treatment sessions. The purpose of this research study is to evaluate the safety and tolerability of hypofractionated radiation therapy.
Hypofractionated radiation therapy uses the same total radiation dose, but the dose is div...MORE |
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| Number: RTOG 1115 |
Principal Investigator: Michalski, Jeff |
| Title: Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with A GNRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GNRH Agonist and TAK-700 for Men with High Risk Prostate Cancer |
| Description: The purpose of this study is to compare the effects of hormone therapy (androgen
deprivation) and TAK-700 plus radiation therapy with hormone therapy (androgen deprivation)and radiation therapy on you and your prostate cancer to find out which therapy is better. TAK-700 is an experimental drug, whi...MORE |
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| Number: RTOG 0938 |
Principal Investigator: Michalski, Jeff |
| Title: A Randomized Phase II Trial of Hypofractionated Radiotherapy for Favorable Risk Prostate Cancer |
| Description: The purpose of this study is to compare two methods of delivering high dose radiation to the prostate to see if the effects of the treatments are similar. Both methods have been studied previously and are considered promising treatment approaches. Standard radiation therapy can involve daily treatme...MORE |
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| Number: RTOG 0924 |
Principal Investigator: Michalski, Jeff |
| Title: Androgen Deprivation Therapy and High Dose Radiotherapy With or Without Whole-Pelvic Radiotherapy in Unfavorable Intermediate or Favorable High Risk Prostate Cancer: A Phase III Randomized Trial |
| Description: The purpose of this study is to compare the effects of hormone therapy (androgen deprivation) and radiation therapy to the prostate gland and seminal vesicles with hormone therapy and radiation therapy to the whole pelvic body area on you and your prostate cancer to find out which is better.
There ...MORE |
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| Number: RTOG 0815 |
Principal Investigator: Michalski, Jeff |
| Title: A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy For Patients With Intermediate-Risk Prostate Cancer |
| Description: The purpose of this study is to compare the effects of dose-escalated radiation therapy with or without hormone therapy on prostate cancer. Prior studies have suggested possible advantages to the administration of
hormonal therapy with radiation. However, those studies were performed with radiation...MORE |
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| Number: RTOG 0534 |
Principal Investigator: Michalski, Jeff |
| Title: A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy |
| Description: The purpose of this study is to compare the effects, good and/or bad of three standard of care treatment methods on participants and their cancer.
External beam radiation therapy is one of the standard treatments for men with prostate cancer who have a rising PSA after surgery. Different method...MORE |
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| Number: RTOG 0526 |
Principal Investigator: Michalski, Jeff |
| Title: A Prospective Phase II Trial of Transperineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Adenocarcinoma Following External Beam Radiotherapy |
| Description: The purpose of this research study is to evaluate the safety and effectiveness of brachytherapy (radiation
seed implants) as treatment for prostate cancer that has reappeared in the prostate after external radiotherapy. Brachytherapy for prostate cancer delivers radiation directly into the prostate...MORE |
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| Number: CALGB S1216 |
Principal Investigator: Picus, Joel |
| Title: A Phase III Randomized Trial Comparing Androgen Deprivaton Therapy + TAK-700 with Androgen Deprivation Therapy + Bicalutamide in Patients with newly Diagnosed Metastatic Hormone Sensitive Prostate Cancer (S1216) |
| Description: The purpose of this study is to find out what effects there are to adding the new investigational drug TAK-700 to standard hormone therapy which is used to treat prostate cancer as compared to the standard of hormone therapy alone....MORE |
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| Number: CALGB 90203 |
Principal Investigator: Picus, Joel |
| Title: A Randomized Phase III Study of Neo-Adjuvant Docetaxel and Androgen Deprivation Prior to Radical Prostatectomy versus Immediate Radical Prostatectomy in Patients with High-Risk, Clinically Localized Prostate Cancer |
| Description: The purpose of this study is to compare the effects (good and bad) of the combination of chemotherapy and hormone therapy followed by radical prostatectomy (surgery to remove your prostate) with radical prostatectomy alone to see which is better.
This research is being done because many men with...MORE |
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| Number: 201208130 |
Principal Investigator: Picus, Joel |
| Title: A Randomized Phase 3 Study Comparing Cabazitaxel/Prednisone in Combination with Custirsen (OGX-011) to Cabazitaxel/Prednisone for Second-Line Chemotherapy in Men with Metastatic Castrate Resistant Prostate Cancer |
| Description: The purpose of this research study is to find out if being treated with cabazitaxel, prednisone and the experimental drug custirsen is better than cabazitaxel and prednisone alone at increasing survival in subjects with metastatic, castrate resistant prostate cancer. The study will also see if custi...MORE |
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| Number: 201208111 |
Principal Investigator: Picus, Joel |
| Title: A Study of HSP90 Inhibitor AT13387 Alone or in Combination with Abiraterone Acetate in the Treatment of Castration-Resistant Prostate Cancer (CRPC) no Longer Responding to Abiraterone |
| Description: The purpose of this research study is to look at the safety and tolerability of AT13387 when given alone or in combination with abiraterone acetate and steroids, and to find out the best treatment plan for AT13387 alone and in combination with abiraterone acetate and steroids when given to patients ...MORE |
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| Number: 201208084 |
Principal Investigator: Roth, Bruce |
| Title: A Multicenter Phase 2, Randomized, Double-Blind, Efficacy and Safety Study of Enzalutamide vs. Bicalutamide in Men with Prostate Cancer Who Have Failed Primary Androgen Deprivation Therapy |
| Description: The purpose of this study is to compare the effect of treatment with enzalutamide to the effect of treatment with bicalutamide on prostate cancer in patients whose prostate cancer has progressed while receiving hormone therapy....MORE |
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| Number: 201111165 |
Principal Investigator: Roth, Bruce |
| Title: A Phase 3, randomized, double-blind, controlled trial of cabozantinib (XL184) vs. mitoxantrone plus prednisone in men with previously treated symptomatic castration-resistant prostate cancer |
| Description: The purpose of this research study is to see if cabozantinib is effective in reducing pain for patients with prostate cancer compared with mitoxantrone plus prednisone....MORE |
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| Number: CALGB 70807 |
Principal Investigator: Strope, Seth |
| Title: The Men’s Eating and Living (MEAL) Study: A Randomized Trial of Diet to Alter Disease
Progression in Prostate Cancer Patients on Active Surveillance |
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| Number: 201102378 |
Principal Investigator: Grubb, III, Robert |
| Title: Feasibility Study of Prostate Tumor Localization for Focal Cryoblation of Prostate Carcinoma |
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| Number: 201110129 |
Principal Investigator: Figenshau, R. Sherburne |
| Title: A Double-blind, Placebo-controlled Study to Evaluate New or Worsening Lens Opacifications in Subjects with Non-metastatic Prostate Cancer Receiving Denosumab for Bone Loss due to Androgen-Deprivation Therapy |
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| Number: 201108010 |
Principal Investigator: Wilson, Richard |
| Title: Germline Sequencing for Aggressive Prostate Carcinoma |
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| Number: 201103379 |
Principal Investigator: Bullock, Arnold |
| Title: The Role of Saturation Biopsy using a 3-D,Transrectal Imaging Technique (TargetScan) in Prostate Cancer Detection and Management |
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| Number: 201103038 |
Principal Investigator: Strope, Seth |
| Title: Assessing Overall Survival and Metastasis Free Survival Following Radical Prostatectomy or Radiation Therapy for Localized Prostate Cancer |
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| Number: 201108327 |
Principal Investigator: Wang-Gillam, Andrea |
| Title: Phase I Study of Erlotinib and Temsirolimus in Resistant Solid Malignancies |
| Description: The purpose of this study is to determine the maximum tolerated dose and side effects of the combination of two drugs, temsirolimus and erlotinib, used to treat solid tumor cancers. Temsirolimus is approved by the Food and Drug Administration (FDA) for treatment of renal cancer and is considered inv...MORE |
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| Number: 201107068 |
Principal Investigator: Lockhart, A. Craig |
| Title: Phase I Safety and Pharmacokinetic Study of XRP6258 (Cabazitaxel) In Advanced Solid Tumor Patients with Varying Degrees of Hepatic Impairment |
| Description: The purpose of this study is to determine if Cabazitaxel is a safe treatment for patients with advanced cancers of different types who also have different levels of liver dysfunction. The highest safe dose of cabazitaxel (the maximum tolerated dose, or MTD) that can be given to patients with your le...MORE |
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| Number: 201102468 |
Principal Investigator: Lockhart, A. Craig |
| Title: An Open-Label Study to Determine the Maximum Tolerated Dose of the PARP Inhibitor CEP-9722 When Administered as a Single Agent in Patients With
Advanced or Metastatic Solid Tumors |
| Description: There are two parts to this research study. The purpose of Part 1 is to find out the highest safe dose of the investigational drug CEP-9722. “Investigational” means that the study drug has not been approved by the United States Food & Drug Administration (F.D.A). Part 2 of the study is to find out m...MORE |
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| Number: 201102462 |
Principal Investigator: Lockhart, A. Craig |
| Title: A Phase 1b, Multi-Center, Open Label, Uncontrolled, Serial Cohort, Dose Escalation Study of the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Daily Oral Doses of ZSTK474 in Subjects with Advanced Solid Malignancies |
| Description: The main purpose of this study is to find out if the drug ZSTK474 is safe in people who have advanced cancers.
ZSTK474 is an investigational (experimental) drug. This means it has not been approved by the Food and Drug Administration (FDA). It is not currently on the market in any country. This stu...MORE |
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