| Number: CTSU S1011 |
Principal Investigator: Grubb, III, Robert |
| Title: A Phase III Surgical Trial to Evaluate the Benefit of a Standard Versus an Extended Pelvic Lymphadenectomy Performed At Time of Radial Cystectomy For Muscle Invasive Urothelial Cancer. |
| Description: The purpose of this study is to compare the effects, good and/or bad, of performing a standard lymph node removal versus an extended lymph node removal for patients with muscle invasive urothelial cancer....MORE |
| ___________________________________________________________________________________________________ |
| Number: CALGB 90601 |
Principal Investigator: Picus, Joel |
| Title: A Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin, And Bevacizumab to Gemcitabine, Cisplatin, and Placebo in Patients with Advanced Transitional Cell Carcinoma |
| Description: The purpose of this study is to compare the effects, good and/or bad, of the combination of the chemotherapy drugs gemcitabine and cisplatin with the combination of gemcitabine, cisplatin, and the experimental drug bevacizumab on transitional cell cancer to find out which is better....MORE |
| ___________________________________________________________________________________________________ |
| Number: 201110201 |
Principal Investigator: Roth, Bruce |
| Title: A Randomized, Double-blind Phase 2 Study Comparing Gemcitabine and Cisplatin in Combination with OGX-427 or Placebo in Patients with Advanced Transitional Cell Carcinoma |
| Description: The purpose of this research study is to find out if treatment with gemcitabine, cisplatin and study drug (OGX-427) can increase survival in subjects with TCC compared to gemcitabine, cisplatin and placebo....MORE |
| ___________________________________________________________________________________________________ |
| Number: 201108400 |
Principal Investigator: Grubb, III, Robert |
| Title: Analysis of Urine and Tissue Proteomics in Bladder Cancer |
| ___________________________________________________________________________________________________ |
| Number: 201203138 |
Principal Investigator: Strope, Seth |
| Title: Assessing the Quality of Initial Intra-Operative Staging for Bladder Cancer |
| ___________________________________________________________________________________________________ |
| Number: 201107136 |
Principal Investigator: Strope, Seth |
| Title: Retrospective and Prospective Evaluation of Outcomes after Radical Cystectomy for Bladder Cancer |
| ___________________________________________________________________________________________________ |
| Number: 201108327 |
Principal Investigator: Wang-Gillam, Andrea |
| Title: Phase I Study of Erlotinib and Temsirolimus in Resistant Solid Malignancies |
| Description: The purpose of this study is to determine the maximum tolerated dose and side effects of the combination of two drugs, temsirolimus and erlotinib, used to treat solid tumor cancers. Temsirolimus is approved by the Food and Drug Administration (FDA) for treatment of renal cancer and is considered inv...MORE |
| ___________________________________________________________________________________________________ |
| Number: 201107068 |
Principal Investigator: Lockhart, A. Craig |
| Title: Phase I Safety and Pharmacokinetic Study of XRP6258 (Cabazitaxel) In Advanced Solid Tumor Patients with Varying Degrees of Hepatic Impairment |
| Description: The purpose of this study is to determine if Cabazitaxel is a safe treatment for patients with advanced cancers of different types who also have different levels of liver dysfunction. The highest safe dose of cabazitaxel (the maximum tolerated dose, or MTD) that can be given to patients with your le...MORE |
| ___________________________________________________________________________________________________ |
| Number: 201102462 |
Principal Investigator: Lockhart, A. Craig |
| Title: A Phase 1b, Multi-Center, Open Label, Uncontrolled, Serial Cohort, Dose Escalation Study of the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Daily Oral Doses of ZSTK474 in Subjects with Advanced Solid Malignancies |
| Description: The main purpose of this study is to find out if the drug ZSTK474 is safe in people who have advanced cancers.
ZSTK474 is an investigational (experimental) drug. This means it has not been approved by the Food and Drug Administration (FDA). It is not currently on the market in any country. This stu...MORE |
| ___________________________________________________________________________________________________ |