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CLINICAL TRIAL SEARCH RESULTS

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 Number: 201404056 Principal Investigator: Bartlett, Nancy
Title: A Phase I Trial of Brentuximab Vedotin in Combination with Lenalidomide in Relapsed or Refractory Diffuse Large B-cell Lymphoma
Description: The purpose of this research study is to find the maximum tolerated dose of two drugs being given in combination for the treatment of your disease: brentuximab vedotin and lenalidomide. We also want to look at the side effects of giving these drugs together, as well as how your disease responds to t...MORE
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 Number: 201204071 Principal Investigator: Wagner-Johnston, Nina
Title: A Phase I/II Institutional Study of Abraxane in Recurrent and Refractory Lymphoma
Description: The purpose of this research study is to find the maximum tolerated dose for Abraxane as well as discover what side effects are associated with its use in patients with lymphoma and how the disease responds to Abraxane....MORE
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 Number: 201101864 Principal Investigator: Stockerl-Goldstein, Keith
Title: Autologous Followed by Non-myeloablative Allogeneic Transplantation for Non-Hodgkin's Lymphoma
Description: You may be invited to participate in a research study to treat non-Hodgkin’s lymphoma. The treatment plan consists of an autologous hematopoietic (blood) cell transplant followed by a non-myeloablative allogeneic transplantation (transplant from another individual). An autologous transplant is don...MORE
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 Number: CTSU S1001 Principal Investigator: Bartlett, Nancy
Title: A Phase II Trial of PET-Directed Therapy for Limited Stage Diffuse Large B-Cell Lymphoma (DLBCL) (S1001)
Description: This study uses a radiologic test called a PET/CT scan to determine treatment after initial doses of a standard FDA approved chemotherapy regimen called "R-CHOP". The purpose of the study is to give more intensive treatment to patients whose PET/CT scan shows that they are at a greater chance of sti...MORE
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 Number: CTSU 9177 Principal Investigator: Bartlett, Nancy
Title: Phase II Study of Dose-Adjusted EPOCH +/- Rituximab in Adults with Untreated Burkitt Lymphoma, C-Myc Positive Diffuse Large B-Cell Lymphoma and Plasmablastic Lymphoma (9177)
Description: The purpose of this research study is to compare the good and/or bad effects of an investigational approach to treating certain types of lymphoma....MORE
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 Number: CALGB CTSU E1411 Principal Investigator: Bartlett, Nancy
Title: Intergroup Randomized Phase II Four Arm Study In Patients With Previously Untreated Mantle Cell Lymphoma Of Therapy With: Arm A = Rituximab+ Bendamustine Followed By Rituximab Consolidation; Arm B = Rituximab + Bendamustine + Bortezomib Followed By Rituximab Consolidation; Arm C= Rituximab + Bendamustine Followed By Lenalidomide + Rituximab Consolidation or Arm D = Rituximab + Bendamustine + Bortezomib Followed By Lenalidomide + Rituximab Consolidation
Description: This randomized phase II trial studies rituximab, bortezomib, bendamustine, and lenalidomide in treating previously untreated older patients with mantle cell lymphoma....MORE
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 Number: CALGB 51101 Principal Investigator: Wagner-Johnston, Nina
Title: A Randomized Phase II Trial of Myeloablative versus Non-Myeloablative Consolidation Chemotherapy for Newly Diagnosed Primary CNS B-Cell Lymphoma
Description: The purpose of this research study is to find out what effects (good and/or bad) treatment with chemotherapy and stem cell transplant compared with chemotherapy alone will have on primary CNS B-cell lymphoma. Currently the best treatment for patients with primary CNS B-cell lymphoma is not known....MORE
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 Number: CALGB 50904 Principal Investigator: Bartlett, Nancy
Title: A Randomized Phase II Trial of Ofatumumab and Bendamustine vs. Ofatumumab, Bortezomib and Bendamustine in Patients with Untreated Follicular Lymphoma
Description: The purpose of this research study is to find out what effects (good and/or bad) treatment with the combination of ofatumumab and bendamustine or the combination of ofatumumab, bendamustine, and bortezomib has on patients and their lymphoma....MORE
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 Number: AMC 091 Principal Investigator: Ratner, Lee
Title: Phase I and Pharmacokinetic Study of Ibrutinib in HIV-Infected Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Multiple Myeloma
Description: The purpose of this study is to test the safety and effects of ibrutinib (PCI-32765), an anti-cancer drug, in HIV-infected people with certain blood diseases. These diseases may include B-cell non-Hodgkin lymphoma, chronic lymphocytic leukemia, or multiple myeloma. The main purpose is to find out if...MORE
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 Number: AMC 075 Principal Investigator: Ratner, Lee
Title: A Sequential Phase I/Randomized Phase II Trial of Vorinostat and Risk-Adapted Chemotherapy with Rituximab in HIV-Related B-Cell Non-Hodgkin’s Lymphoma
Description: This study is being conducted because scientists think that adding vorinostat therapy may enhance the effectiveness of standard chemotherapy plus rituximab in certain types of lymphoma, and may also have a positive effect against HIV and other viruses in our bodies which can cause lymphoma....MORE
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 Number: 201408033 Principal Investigator: Bartlett, Nancy
Title: A Phase 1/2, Non-randomized, Open-label, Multicenter, Dose Escalation and Expansion Study of Intratumoral Injections of SD-101 in Combination with Localized Low-dose Radiation in Patients with Untreated Low-grade B-cell Lymphoma
Description: The purpose of this study is to learn about the safety of SD-101 and to find out what effects (both good and bad) it has on you and your B-cell Lymphoma when given along with low-dose radiation therapy. SD-101 is being studied as a treatment of Non-Hodgkin’s Lymphoma (NHL), specifically Low Grade B-...MORE
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 Number: 201310010 Principal Investigator: Bartlett, Nancy
Title: A Phase Ib Study Evaluating the Safety, Tolerability, and Anti-Tumor Activity of DCDS4501A in Combination with Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone in Patients with B-Cell Non-Hodgkin's Lymphoma
Description: The purpose of this study is to test an investigational drug called DCDS4501A, in combination with four other drugs, rituximab (Rituxan®, MabThera®), cyclophosphamide, doxorubicin, and prednisone (when given together, referred to as R-CHP). We want to find out what effects, good and/or bad, these dr...MORE
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 Number: 201309086 Principal Investigator: Wagner-Johnston, Nina
Title: A Phase I Open-Label, Multi-Dose, Dose Escalation Study of PRT06270 in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) or B-Cell Non Hodgkin Lymphoma (NHL)
Description: The primary purpose of this research study is to see whether PRT062070 (the study drug) is safe for use in patients with CLL, SLL, or B-cell NHL and to determine the best dose to use for future studies....MORE
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 Number: 201307061 Principal Investigator: Wagner-Johnston, Nina
Title: A Phase 2 Study of IPI-145 in Subjects with Refractory Indolent Non-Hodgkin Lymphoma
Description: This research study because you have indolent non-Hodgkin Lymphoma. The purpose of this research study is to find out if IPI-145 is effective in stopping cancer cells from growing and spreading and to find out the side effects of IPI-145...MORE
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 Number: 201307003 Principal Investigator: Cashen, Amanda
Title: Phase 1 Dose Finding Study of Belinostat plus Cyclophosphamide/Vincristine/Doxorubicin/Prednisone (CHOP) Regimen (BelCHOP) for Treatment of Patients with Peripheral T-cell Lymphoma (PTCL)
Description: The purposes of this study are: Part A (dose escalation) to find the best tolerated dose of belinostat when combined with CHOP and part B (dose expansion) is to determine the safety and tolerability in additional patients treated with the dose find in part A. Patients will receive belinostat plus Cy...MORE
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 Number: 201306054 Principal Investigator: Bartlett, Nancy
Title: A Randomized, Double-blind, Placebo Controlled Phase 3 Study of Ibrutinib in Combination with R-CHOP in Subjects with newly Diagnosed Non-Germinal Center B-Cell Subtypes of DLBCL
Description: The purpose of the study is to compare the effects (both good and bad) of ibrutinib when it is given in combination with rituximab, cyclophsophamide, doxorubicin, vincristine, and prednisone (R-CHOP) to R-CHOP alone in patients with newly diagnosed non-germinal center B-Cell subtype of Diffuse Larg...MORE
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 Number: 201305047 Principal Investigator: Bartlett, Nancy
Title: A phase 2 study of brentuximab vedotin in combination with standard of care treatment (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (RCHOP) as front-line therapy in patients with diffuse large B-cell lymphoma (DLBCL)
Description: This study is being done to test the safety and effectiveness of 2 different doses of brentuximab vedotin when given with a combination of drugs called RCHOP [rituximab, cyclophosphamide, hydroxydaunorubicin (also called doxorubicin), vincristine (Oncovin), and prednisone]....MORE
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 Number: 201301088 Principal Investigator: Bartlett, Nancy
Title: An Open-label Extension Study in Patients 65 Years or Older with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Who Participated in Study PCYC-1115-CA (PCI-32765 versus Chlorambucil) (PCYC-1116-CA)
Description: The purpose of this study is to provide patients who previously participatecd in the PCYC-115-CA study access to the investigational drug, PCI-32765 or alternative treatment....MORE
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 Number: 201209095 Principal Investigator: Ratner, Lee
Title: Multi-Center, Open-Label, Randomized Study of Anti-CCR4 Monoclonal Antibody KW-0761 or Investigator’s Choice in Subjects with Previously Treated Adult T-cell Leukemia-Lymphoma (ATL)
Description: The main purpose of this study is to determine if KW-0761 will work against adult T-cell leukemia-lymphoma that has failed to respond to other treatments, and to evaluate its side effects....MORE
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 Number: 201208155 Principal Investigator: Carson, Kenneth
Title: Open-Label, Multi-Center, Randomized Study of Anti-CCR4 Monoclonal Antibody KW 0761 (mogamulizumab) Versus Vorinostat in Subjects with Previously Treated Cutaneous T-Cell Lymphoma
Description: The purpose of this research study is to determine if KW-0761 will work against cutaneous T-cell lymphoma that has failed to respond to other treatments, and to evaluate its side effects....MORE
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 Number: 201208075 Principal Investigator: Bartlett, Nancy
Title: A randomized, double-blind, placebo-controlled, phase 3 study of brentuximab vedotin and CHP (A+CHP) versus CHOP in the frontline treatment of patients with CD30-positive mature T-cell lymphomas SGN35-014)
Description: This is a clinical trial to compare the efficacy and safety of brentuximab vedotin in combination with CHP with the standard-of-care CHOP in patients with CD30-positive mature T-cell lymphomas....MORE
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 Number: 201204004 Principal Investigator: Bartlett, Nancy
Title: A Phase 2 Randomized Open-label Study of MEDI-551 in Adults with Relapsed or Refractory DLBCL
Description: The overall purpose of the study is to determine if MEDI-551, when used in combination with salvage chemotherapy, Ifosfamide-carboplatin-etoposide (ICE) or Dexamethasone-cytarabine (DHAP) in patients with relapsed or refractory DLBCL who are eligible for autologous stem cell transplant (ASCT), has s...MORE
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 Number: 201201017 Principal Investigator: Bartlett, Nancy
Title: A phase 3 open-label randomized study to compare the efficacy and safety of rituximab plus lenalidomide (cc-5013) versus rituximab plus chemotherapy followed by Rituximab in subjects with previously untreated follicular lymphoma
Description: The purpose of this study is to find out if a drug called lenalidomide when given along with rituximab can help to control the disease and also increase the length of response (complete or partial response) compared to the current standard of care which is rituximab plus chemotherapy treatment....MORE
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 Number: 201109213 Principal Investigator: Bartlett, Nancy
Title: A Phase I Study of Pf-05082566 as a Single Agent in Patients with Advanced Cancer, And in Combination with Rituximab in Patients with Non-Hodgkin’s Lymphoma (NHL)
Description: The purpose of this research study is to learn about the effects of the study drug, PF-05082566, and to find the best dose for treating Non-Hodgkin’s lymphoma....MORE
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 Number: 201108251 Principal Investigator: Cashen, Amanda
Title: Tissue Acquisition for Analysis of Prognostic Factors, Immunology, and Genetic Progression of Lymphoid Malignancies
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