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CLINICAL TRIAL SEARCH RESULTS

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 Number: 201501072 Principal Investigator: Campian, Jian
Title: A Phase I and Open Label, Randomized, Controlled Phase II Study Testing the Safety, Toxicities, and Efficacy of MK-3475 in combination with MRI-guided Laser Ablation in Recurrent Malignant Gliomas
Description: The purpose of this research study is to find the highest dose of a drug called pembrolizumab (MK-3475) that can be given when combined with MLA, and to look at the side effects that people experience when treated with this combination....MORE
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 Number: 201306042 Principal Investigator: Campian, Jian
Title: A Phase II Study of the NovoTTF-100A System, Enhanced by Genomic Analysis to Identify the Genetic Signature of Response in the Treatment of Recurrent Glioblastoma Multiforme
Description: The purpose of this study is to redefine how efficacy of the NovoTTF-100A device is determined by performing whole exome and RNA sequencing to identify the genomic signature of patients who respond to treatment....MORE
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 Number: 201305148 Principal Investigator: Campian, Jian
Title: A Pilot Study of Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Doxorubicin in the Treatment of Recurrent Glioblastoma Multiforme
Description: The purpose of this research study is to use imaging techniques (MRI) and blood tests (biomarkers) to help figure out the best time for chemotherapy to be initiated after the blood brain barrier is disrupted, as it is immediately following a procedure like MRI-guided laser ablation (MLA)....MORE
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 Number: 201304067 Principal Investigator: Campian, Jian
Title: Open-label, Phase 2 study of bevacizumab in children and young adults with neurofibromatosis 2 and progressive vestibular schwannomas that are poor candidates for standard treatment with surgery or radiation
Description: The purpose of this study is to find out what effects, good and/or bad, bevacizumab has on the patient and their disease (vestibular schwannoma)....MORE
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 Number: RTOG 1205 Principal Investigator: Huang, Jiayi
Title: Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma
Description: The purpose of this research study is to determine whether adding radiation to bevacizumab is more effective than using bevacizumab alone to treat recurrent glioblastomas. Bevacizumab is a commercially available drug that is FDA approved for the treatment of glioblastoma that has returned after trea...MORE
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 Number: RTOG 0834 Principal Investigator: Robinson, Clifford
Title: Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma: The Catnon Intergroup Trial
Description: The purpose of this study is to determine whether the addition of temozolomide treatment to radiotherapy (concomitant treatment) or the addition of temozolomide treatment after completion of radiotherapy on 5 days out of every 28 days for 12 months (adjuvant treatment) will improve the results of th...MORE
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 Number: NRG BN001 Principal Investigator: Huang, Jiayi
Title: Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy versus Conventional Photon Irradiation with Concomitant and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma
Description: The purpose of this study is to compare a different radiation therapy schedule and higher radiation dose [higher dose group] to the standard dose of radiation therapy [standard dose group]. Both groups will receive usual chemotherapy, temozolomide. The higher radiotherapy dose could shrink your can...MORE
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 Number: CTSU N0577 Principal Investigator: Campian, Jian
Title: Phase III Intergroup Study of Temozolomide Alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma
Description: The purpose of this study is to compare how well three different treatment regimens are able to treat anaplastic glioma, a type of brain tumor. The three treatments we are comparing are 1) radiation therapy with temozolomide chemotherapy followed by additional temozolomide chemotherapy; 2) radiatio...MORE
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 Number: CALGB A071102 Principal Investigator: Campian, Jian
Title: A Phase II/III Randomized Trial of Veliparib or Placebo in Combination with Adjuvant Temozolomide in Newly Diagnosed Glioblastoma with MGMT Promoter Hypermethylation
Description: The purpose of the study is to see if combining the experimental drug veliparib with standard temozolomide treatment helps improve survival in patients with glioblastoma with MGMT promoter hypermethylation....MORE
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 Number: CALGB A071101 Principal Investigator: Campian, Jian
Title: A Phase II Randomized Trial Comparing the Efficacy of Heat Shock Protein-Peptide Complex-96 (HSPPC-96) (NSC #725085, Alliance IND #15380) Vaccine Given with Bevacizumab Versus Bevacizumab Alone in the Treatment of Surgically Resectable Recurrent Glioblastoma Multiforme (GBM)
Description: The purpose of this study is to compare the effects of a vaccine called heat shock protein peptide complex 96 (HSPPC-96) given with a drug called bevacizumab to bevacizumab alone in patients with brain tumors....MORE
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 Number: 201412102 Principal Investigator: Dunn, Gavin
Title: Phase 2 study to Evaluate the Clinical Efficacy and Safety of MEDI4736 in Patients with Glioblastoma (GBM)
Description: This is a research study. We invite you to participate in this research study because you have glioblastoma.The purpose of this research study is to evaluate MEDI4736 as a possible treatment for glioblastoma (GBM). The study will also see how much MEDI4736 is in your blood at various times and wheth...MORE
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 Number: 201411131 Principal Investigator: Campian, Jian
Title: Phase 1/2 Dose-Escalation Study of TPI 287 in Combination with Bevacizumab Followed by Randomized Study of the Maximum Tolerated Dose of TPI 287 in Combination with Bevacizumab versus Bevacizumab Alone in Adults with Recurrent Glioblastoma
Description: The purpose of this research study is to test an investigational drug called TPI 287 in combination with an FDA approved drug called bevacizumab (also known as Avastin), and also compare it to patients receiving bevacizumab alone....MORE
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 Number: 201410009 Principal Investigator: Campian, Jian
Title: An Expanded Access Protocol for the Treatment of Glioblastoma Multiforme in Patients with Already Manufactured DCVax®-L, Autologous Dendritic Cells Pulsed with Tumor Lysate Antigen Who Have Screen-Failed Protocol 020221
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 Number: 201407113 Principal Investigator: Campian, Jian
Title: Phase 2 Dose-Escalation Study of TPI 287 in Combination with Bevacizumab in Adults with Recurrent or Progressive Glioblastoma Following a Bevacizumab-Containing Regimen
Description: The purpose of this research study is to test the safety and effectiveness of an investigational drug called TPI 287 in combination with an FDA approved drug called bevacizumab (also known as Avastin)when treating brain tumors....MORE
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 Number: 201110176 Principal Investigator: Campian, Jian
Title: A Phase III Clinical Trial Evaluating DCVax®-Brain, Autologous Dendritic Cells Pulsed with Tumor Lysate Antigen For The Treatment of Glioblastoma Multiforme (GBM)
Description: The purpose of this clinical trial is to determine whether DCVax-Brain can slow the growth and recurrence of brain tumors and whether DCVax-Brain can extend overall survival for patients....MORE
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 Number: 201302018 Principal Investigator: Huang, Jiayi
Title: Assessment of Early Treatment Response of Brain Metastases after Gamma-Knife Radiosurgery Using Dynamic Susceptibility-weighted Contrast-enhanced Perfusion Magnetic Resonance Imaging
Description: The purpose of this research study is to evaluate scans of your brain called perfusion MRIs before and after gamma-knife radiosurgery to see if changes in the scans can predict your response to gamma-knife over the course of a year. We are interested in gathering information about how scans can help...MORE
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 Number: CALGB A221101 Principal Investigator: Campian, Jian
Title: A Phase III Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil®) To Reduce Cancer-Related Fatigue in Patients with Glioblastoma Multiforme (A221101)
Description: The purpose of this research study is to see if taking the study drug, armodafinil, will improve problems with fatigue in patients who have glioblastoma and to see the effects (good and bad) of taking Armodafinil compared to the placebo....MORE
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 Number: 201111001 Principal Investigator: Campian, Jian
Title: Analysis of Histological, Genomic, Molecular, and Clinical Factors in CNS Cancer: the Neuro-Oncology Group
Description: The purpose of this research study is to discover genetic changes associated with cancer by documenting the DNA changes that occur in brain cancer cells. This may lead to better ways of preventing, detecting, and treating cancer and perhaps other diseases as well....MORE
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 Number: 201108374 Principal Investigator: Gutmann, David
Title: Creation of a Neurofibromatosis Type 1 Biospecimen Repository
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 Number: 201104299 Principal Investigator: Kroll, Kristen
Title: Epigenetic regulation in tumor initiating cells of brain tumors
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 Number: 201405021 Principal Investigator: Campian, Jian
Title: Prospective Evaluation of T-cell Immune Status in Patients with Newly Diagnosed High Grade Gliomas
Description: This research is being done to see how lymphocytes are changed in people with high grade gliomas during their treatment course with standard radiation and chemotherapy....MORE
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 Number: 201211019 Principal Investigator: Kim, Albert
Title: Ubiquitin Signaling in Brain Tumors
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 Number: 201405049 Principal Investigator: Govindan, Ramaswamy
Title: A Phase 1 Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493, a pan-Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinase Inhibitor, in Subjects with Advanced or Refractory Solid Tumors or Lymphoma
Description: The purpose of this research study is to determine the effectiveness of the study drug, JNJ-42756493, on relapsed or refractory solid tumors....MORE
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