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CLINICAL TRIAL SEARCH RESULTS

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 Number: 201306042 Principal Investigator: Tran, David
Title: A Phase II Study of the NovoTTF-100A System, Enhanced by Genomic Analysis to Identify the Genetic Signature of Response in the Treatment of Recurrent Glioblastoma Multiforme
Description: The purpose of this study is to redefine how efficacy of the NovoTTF-100A device is determined by performing whole exome and RNA sequencing to identify the genomic signature of patients who respond to treatment....MORE
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 Number: 201305148 Principal Investigator: Tran, David
Title: A Pilot Study of Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Doxorubicin in the Treatment of Recurrent Glioblastoma Multiforme
Description: The purpose of this research study is to use imaging techniques (MRI) and blood tests (biomarkers) to help figure out the best time for chemotherapy to be initiated after the blood brain barrier is disrupted, as it is immediately following a procedure like MRI-guided laser ablation (MLA)....MORE
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 Number: 201304067 Principal Investigator: Tran, David
Title: Open-label, Phase 2 study of bevacizumab in children and young adults with neurofibromatosis 2 and progressive vestibular schwannomas that are poor candidates for standard treatment with surgery or radiation
Description: The purpose of this study is to find out what effects, good and/or bad, bevacizumab has on the patient and their disease (vestibular schwannoma)....MORE
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 Number: RTOG 1205 Principal Investigator: Huang, Jiayi
Title: Randomized Phase II Trial of Concurrent Bevacizumab and Re-Irradiation versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma
Description: The purpose of this research study is to determine whether adding radiation to bevacizumab is more effective than using bevacizumab alone to treat recurrent glioblastomas. Bevacizumab is a commercially available drug that is FDA approved for the treatment of glioblastoma that has returned after trea...MORE
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 Number: RTOG 0834 Principal Investigator: Robinson, Clifford
Title: Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma: The Catnon Intergroup Trial
Description: The purpose of this study is to determine whether the addition of temozolomide treatment to radiotherapy (concomitant treatment) or the addition of temozolomide treatment after completion of radiotherapy on 5 days out of every 28 days for 12 months (adjuvant treatment) will improve the results of th...MORE
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 Number: CTSU N1174 Principal Investigator: Tran, David
Title: Phase I/Comparative Randomized Phase II Trial of TRC105 plus Bevacizumab versus Bevacizumab in Bevacizumab-Naïve Patients with Recurrent Glioblastoma Multiforme
Description: The purpose of this study is to compare any effects, good and bad, of using a combination of the chemotherapy drug, TRC105, with bevacizumab to using bevacizumab alone. The study is also looking to see if TRC105 with bevacizumab could possibly shrink cancer....MORE
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 Number: CTSU N0577 Principal Investigator: Tran, David
Title: Phase III Intergroup Study of Temozolomide Alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma
Description: The purpose of this study is to compare how well three different treatment regimens are able to treat anaplastic glioma, a type of brain tumor. The three treatments we are comparing are 1) radiation therapy with temozolomide chemotherapy followed by additional temozolomide chemotherapy; 2) radiatio...MORE
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 Number: CALGB A221101 Principal Investigator: Tran, David
Title: A Phase III Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil®) To Reduce Cancer-Related Fatigue in Patients with Glioblastoma Multiforme (A221101)
Description: The purpose of this research study is to see if taking the study drug, armodafinil, will improve problems with fatigue in patients who have glioblastoma and to see the effects (good and bad) of taking Armodafinil compared to the placebo....MORE
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 Number: CALGB A071101 Principal Investigator: Tran, David
Title: A Phase II Randomized Trial Comparing the Efficacy of Heat Shock Protein-Peptide Complex-96 (HSPPC-96) (NSC #725085, Alliance IND #15380) Vaccine Given with Bevacizumab Versus Bevacizumab Alone in the Treatment of Surgically Resectable Recurrent Glioblastoma Multiforme (GBM)
Description: The purpose of this study is to compare the effects of a vaccine called heat shock protein peptide complex 96 (HSPPC-96) given with a drug called bevacizumab to bevacizumab alone in patients with brain tumors....MORE
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 Number: 201407113 Principal Investigator: Campian, Jian
Title: Phase 2 Dose-Escalation Study of TPI 287 in Combination with Bevacizumab in Adults with Recurrent or Progressive Glioblastoma Following a Bevacizumab-Containing Regimen
Description: The purpose of this research study is to test the safety and effectiveness of an investigational drug called TPI 287 in combination with an FDA approved drug called bevacizumab (also known as Avastin)when treating brain tumors....MORE
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 Number: 201209125 Principal Investigator: Tran, David
Title: A Phase II Study of Rindopepimut/GM-CSF in Patients with Relapsed EGFRvIII-Positive Glioblastoma (CDX110-06)
Description: The purpose of this research study is to find out whether adding rindopepimut and GM-CSF to bevacizumab helps to shrink brain tumors, prevent brain tumors from growing, or help patients with brain tumors live longer than treatment with bevacizumab alone....MORE
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 Number: 201206018 Principal Investigator: Tran, David
Title: A Prospective, Multi-center Trial of NovoTTF-100A Together With Temozolomide Compared to Temozolomide Alone in Patients with Newly Diagnosed GBM
Description: The study is a prospective, randomly controlled pivotal trial, designed to test the efficacy and safety of a medical device, the NovoTTF-100A, in addition to the best standard of care in the treatment of patients with newly diagnosed glioblastoma. The device is an experimental, portable, battery op...MORE
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 Number: 201202091 Principal Investigator: Tran, David
Title: An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF with Adjuvant Temozolomide in Patients with Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma (The “ACT IV” Study)
Description: The purpose of this research study is to find out whether adding treatment with an investigational vaccine, rindopepimut, to the commonly used chemotherapy drug called temozolomide helps to shrink brain tumors or prevents brain tumors from growing and helps patients with brain tumors live longer tha...MORE
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 Number: 201110176 Principal Investigator: Tran, David
Title: A Phase II Clinical Trial Evaluating DCVax®-Brain, Autologous Dendritic Cells Pulsed with Tumor Lysate Antigen For The Treatment of Glioblastoma Multiforme (GBM)
Description: The purpose of this clinical trial is to determine whether DCVax-Brain can slow the growth and recurrence of brain tumors and whether DCVax-Brain can extend overall survival for patients....MORE
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 Number: 201302018 Principal Investigator: Huang, Jiayi
Title: Assessment of Early Treatment Response of Brain Metastases after Gamma-Knife Radiosurgery Using Dynamic Susceptibility-weighted Contrast-enhanced Perfusion Magnetic Resonance Imaging
Description: The purpose of this research study is to evaluate scans of your brain called perfusion MRIs before and after gamma-knife radiosurgery to see if changes in the scans can predict your response to gamma-knife over the course of a year. We are interested in gathering information about how scans can help...MORE
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 Number: 201107036 Principal Investigator: Benzinger, Tammie
Title: qBOLD MR Measurements of Oxygen Extraction Fraction in Patients with Brain Tumors
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 Number: 201109032 Principal Investigator: Chicoine, Michael
Title: Intraoperative MRI Patient Repository
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 Number: 201011809 Principal Investigator: Marcus, Daniel
Title: BRIN Resources Facilitate the Personalization of Malignant Brain Tumor- This Study is also known as "CONDR" (Comprehensive Neurooncology Data Repository)
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 Number: RTOG 0925 Principal Investigator: Robinson, Clifford
Title: Natural History of Postoperative Cognitive Function, Quality of Life, And Seizure Control in Patients with Supratentorial Low-Risk Grade II Glioma
Description: The purpose of this research study is to understand the effects of your brain tumor and surgery on your cognitive function (thinking abilities, memory), quality of life, and seizures....MORE
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 Number: 201111001 Principal Investigator: Tran, David
Title: Analysis of Histological, Genomic, Molecular, and Clinical Factors in CNS Cancer: the Neuro-Oncology Group
Description: The purpose of this research study is to discover genetic changes associated with cancer by documenting the DNA changes that occur in brain cancer cells. This may lead to better ways of preventing, detecting, and treating cancer and perhaps other diseases as well....MORE
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 Number: 201108374 Principal Investigator: Gutmann, David
Title: Creation of a Neurofibromatosis Type 1 Biospecimen Repository
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 Number: 201104299 Principal Investigator: Kroll, Kristen
Title: Epigenetic regulation in tumor initiating cells of brain tumors
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 Number: 201102299 Principal Investigator: Rubin, Joshua
Title: Molecular Analyses of Human Brain Tumors
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 Number: 201405021 Principal Investigator: Campian, Jian
Title: Prospective Evaluation of T-cell Immune Status in Patients with Newly Diagnosed High Grade Gliomas
Description: This research is being done to see how lymphocytes are changed in people with high grade gliomas during their treatment course with standard radiation and chemotherapy....MORE
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 Number: 201012772 Principal Investigator: Chicoine, Michael
Title: Outcomes Analyses in Patients with Brain Tumors
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