David Ornitz, MD, PhD

David Ornitz, MD, PhD

Primary Academic Title

Alumni Endowed Professor of Developmental Biology, Washington University School of Medicine

Research Interest

Fibroblast growth factors and the regulation of organogenesis in the mouse. Key words: Growth factors, fibroblast growth factors, FGFs, FGF receptors, skeletal development, brain development, lung development, heart development, pancreas development, stomach development, spleen development, signaling pathways, knockout mice, transgenic mice.

Education

  • 1987: PhD, biochemistry, University of Washington, Seattle
  • 1988: MD, University of Washington

Training

  • 1988 - 1992: Postdoctoral fellow, genetics, Harvard Medical School, Boston

Selected Research Publications

Multi-organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2).
  • Bodmer NK, Knutsen RH, Roth RA, [...] Ornitz DM
  • Dev Dyn 2024
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway.
  • Lee C, Chen R, Sun G, [...] Ornitz DM, [...] Li X
  • Signal Transduct Target Ther 2023
Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer.
  • Ishioka K, Yasuda H, Hamamoto J, [...] Ornitz DM, [...] Fukunaga K
  • Cancer Res 2021
ETV4 and ETV5 drive synovial sarcoma through cell cycle and DUX4 embryonic pathway control.
  • DeSalvo J, Ban Y, Li L, [...] Ornitz DM, [...] Eid JE
  • J Clin Invest 2021

View All Publications