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Tumor Immunology

Program Co-Leaders: Robert Schreiber, PhD, and William Gillanders, MD

Eleven years ago, a decision was made to promote tumor immunology research at Washington University by including a tumor immunology program as an integral component of a newly forming NCI-accredited Comprehensive Cancer Center. This strategy has yielded significant success, and today the number of laboratories performing tumor immunology-related research has risen significantly. More importantly, the last six years have seen an even more significant rise in translational and/or clinical tumor immunology research. Based on the advances in our understanding of immune system-tumor interactions that have occurred over the last six years and the research strengths/interests of our program members, the efforts of the Tumor Immunology Program are now focused into four thematic areas: (1) the molecular basis of immune recognition of cancer; (2) mechanisms underlying development of host-protective, immune-effector functions; (3) pro-tumorigenic inflammation and immunosuppression; and (4) tumor immunotherapy.

The long-range goal of the Tumor Immunology Program is to encourage the development of cutting-edge tumor immunology research and facilitate its direct translation into novel diagnostic or immunotherapeutic protocols. Toward these ends, the following four immediate goals will be pursued:

  • Continued development of new experimental tumor models using transgenic and gene-targeted mice that more closely recapitulate clinical aspects of human cancer
  • Definition of the structures/antigens of tumors that are the targets of innate and adaptive immune recognition and exploration of mechanisms to enhance the sensitivity/specificity of the recognition process
  • Elucidation of the roles of innate and adaptive immune response components in either promoting or suppressing anti-tumor immune responses
  • Exploration of new avenues to increase the number of inter-departmental and/or collaborative tumor immunology research projects.

The program will achieve these goals by continuing to sponsor a number of interactive scientific forums for its members and their research teams and by employing the resources of the Siteman Cancer Center and its cores to encourage the active and interactive participation of both its basic and clinically oriented members. The Tumor Immunology Research Program currently consists of 28 members from five departments in the School of Medicine.

 

Click on the name to see detailed information about the selected professional.

NameDepartment
Paul Allen, PhD Pathology and Immunology
George Ansstas, MD Internal Medicine
Deepta Bhattacharya, PhD Pathology and Immunology
Beatriz Carreno, PhD Internal Medicine
William Chapman, MD Surgery
Kyunghee Choi, PhD Pathology and Immunology
Marco Colonna, MD Pathology and Immunology
Lynn Cornelius, MD Internal Medicine
David DeNardo, PhD Internal Medicine
Timothy Eberlein, MD Surgery
Thomas Ferguson, PhD Ophthalmology and Visual Sciences
William Gillanders, MD Surgery
Simon Goedegebuure, PhD Surgery
Jonathan Green, MD Internal Medicine
William Hawkins, MD Surgery
Robert Hayashi, MD Pediatrics
Chyi-Song Hsieh, MD, PhD Internal Medicine
Eynav Klechevsky, PhD Pathology and Immunology
A. Sasha Krupnick, MD Surgery
Deborah Lenschow, MD, PhD Internal Medicine
Kian-Huat Lim, MD, PhD Internal Medicine
David Linehan, MD Surgery
Gerald Linette, MD, PhD Internal Medicine
Thalachallour Mohanakumar, PhD Surgery
Kenneth Murphy, MD, PhD Pathology and Immunology
Rodney Newberry, MD Internal Medicine
Eugene Oltz, PhD Pathology and Immunology
Robert Schreiber, PhD Pathology and Immunology
Andrey Shaw, MD Pathology and Immunology
Kathleen Sheehan, PhD Pathology and Immunology
Barry Sleckman, MD, PhD Pathology and Immunology
Dirk Spitzer, PhD Surgery
Thaddeus Stappenbeck, MD, PhD Pathology and Immunology
Wojciech Swat, PhD Pathology and Immunology
Sandeep Tripathy, MD, PhD Internal Medicine
Emil Unanue, MD Pathology and Immunology
Ravindra Uppaluri, MD, PhD Otolaryngology
Herbert Virgin, MD, PhD Pathology and Immunology
Wayne Yokoyama, MD Internal Medicine