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1997

Timothy Ley, MD, develops a mouse model of promyelocytic leukemia.

A group of researchers headed by David Schlessinger, PhD, completes the first high-resolution map of chromosome X.

The Breast Health Center opens on the fifth floor of the Kingshighway Building at Barnes-Jewish Hosptial. It is designed to provide comprehensive, high-quality breast evaluation in one visit.

One of the first papers to be published on PET scanning and its use in assessing patients with esophageal cancer is published by the thoracic surgery staff and nuclear medicine physicians at Washington University School of Medicine.

In fulfillment of the campus integration plan, oncology services begin moving to Barnes-Jewish Hospital's north campus. The inpatient medical oncology service is consolidated on patient care unit 4900.

1998
Jeffrey Gordon, MD, develops a mouse model of prostate cancer.

Stanley Korsmeyer, MD, wins the General Motors Cancer Research Prize for showing that the failure of cells to undergo programmed cell death can lead to cancer.

The Gamma Knife, one of only 36 in the country, is installed at Barnes-Jewish Hospital. This therapeutic modality allows the very precise administration of high doses of radiation to targets within the brain, including brain tumors.

Through a press conference at the National Academy of Sciences in Washington, D.C., and a paper published in Science, the Genome Sequencing Center announces that the C. elegans gene sequence is complete. This is the first genome of a multicellular organism to be sequenced. It also is the largest genome sequenced to date, with 100 million base pairs.

Timothy Eberlein, MD, becomes interim director of the cancer center at Washington University School of Medicine, and the center is given department status.

Ralph Dacey, MD, uses a magnetic stereotaxis device for the first time in a human patient to biopsy a brain tumor. This device uses externally applied magnetic fields to direct biopsy catheters and other tools within the brain. This unique device was first developed at Barnes-Jewish Hospital in conjunction with Stereotaxis Inc., a St. Louis-based biotechnology company.

Joel Cooper, MD, and colleagues publish a report in the Journal of Thoracic and Cardiovascular Surgery on combining lung volume reduction surgery and resection in patients with early stage lung cancer. It shows that patients who were previously not candidates for this surgery could be successfully treated with curative resection.

Dedicated psychologists join in providing psychosocial services for cancer patients and their families.
1999
The NIH awards $218.4 million to the Genome Sequencing Center to sequence about one-third of the human genome by the year 2003.

Lee Ratner, MD, reports the first combination of chemotherapy with highly active anti-retroviral therapy for the treatment of AIDS lymphoma.

John DiPersio, PhD, and colleagues plan to open a trial in which they will be testing UV in psoralin-treated lymphocytes. They attempt to increase the donor pool substantially by using mismatched donors. They also work on preclinical models to test their ability to genetically modify T cells by putting suicide genes in them to kill them and thus control graft vs. host disease.

Scientists uncover evidence about the workings of one of the gateways to the brain. Their findings suggest approaches to control the gateway with drugs, which may have implications for cancer therapy. David Piwnica-Worms, PhD, is the study's principal investigator.

A landmark multi-institutional study — including Washington University researchers Perry Grigsby, MD, David Mutch, MD, and others — shows that women with invasive cervical cancer benefit from the addition of chemotherapy to their radiation treatment.

Timothy Eberlein, MD is appointed permanent director of the cancer center.

In recognition of a $35 million dollar gift, the cancer center is renamed the Alvin J.Siteman Cancer Center.
2001
The Siteman Cancer Center receives national recognition by becoming a National Cancer Institute-designated Cancer Center.

A new Siteman outpatient care facility opens within the Center for Advanced Medicine on the Washington University Medical Center campus.

In September 2001,
Washington University School of Medicine establishes the Department of Radiation Oncology under the leadership of Carlos Perez, MD.

Under the direction of Timothy Graubert, MD, Siteman's 11th core laboratory, the Siteman Flow Cytometry, opens in fall 2001.
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