Sheila Stewart, PhD

Sheila Stewart, PhD

Primary Academic Title

Professor of Cell Biology and Physiology, Washington University School of Medicine.

Research Interest

Cellular immortality is one of the defining characteristics of malignant growth. Therefore, understanding how cellular lifespan is controlled at the molecular level is a central theme in the laboratory. The telomere, a DNA-protein structure located at the termini of linear chromosomes, plays a central role in controlling cellular mortality. Therefore, we are particularly interested in understanding how it is maintained. In addition, delineating the signal transduction machinery that is responsible for monitoring the telomere and eliciting modifications of the telomere is of critical importance to understanding how incipient cancer cells obtain immortality.

Education

  • 1996: PhD, microbiology and immunology, University of California, Los Angeles

Training

  • 1996 - 1998: Postdoctoral fellow, University of California, Los Angeles
  • 1998 - 2003: Postdoctoral fellow, Whitehead Institute for Biomedical Research, Cambridge, Mass.

Selected Research Publications

p38MAPKα Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy.
  • Faget DV, Luo X, Inkman MJ, [...] Stewart SA
  • Cancer Discov 2023
Stress response regulates cancer fibroblasts.
  • Faget DV, Stewart SA
  • Nat Cell Biol 2022
Gene expression predicts dormant metastatic breast cancer cell phenotype.
  • Ren Q, Khoo WH, Corr AP, [...] Stewart SA
  • Breast Cancer Res 2022

View All Publications